A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

Mutations in the gene AK2 are responsible for reticular dysgenesis (RD), a rare and severe form of primary immunodeficiency in children. RD patients have a severely shortened life expectancy and without treatment die, generally from sepsis soon after birth. The only available therapeutic option for...

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Detalles Bibliográficos
Autores principales: Rissone, Alberto, Jimenez, Erin, Bishop, Kevin, Carrington, Blake, Slevin, Claire, Wincovitch, Stephen M., Sood, Raman, Candotti, Fabio, Burgess, Shawn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955229/
https://www.ncbi.nlm.nih.gov/pubmed/31727854
http://dx.doi.org/10.1242/dmm.040170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955229/
https://www.ncbi.nlm.nih.gov/pubmed/31727854
http://dx.doi.org/10.1242/dmm.040170

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