Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme

A robust body of evidence supports the concept that phosphodiesterase 10A (PDE10A) activity in the basal ganglia orchestrates the control of coordinated movement in human subjects. Although human mutations in the PDE10A gene manifest in hyperkinetic movement disorders that phenocopy many features of...

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Detalles Bibliográficos
Autores principales: Tejeda, Gonzalo S., Whiteley, Ellanor L., Deeb, Tarek Z., Bürli, Roland W., Moss, Stephen J., Sheridan, Eamonn, Brandon, Nicholas J., Baillie, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955301/
https://www.ncbi.nlm.nih.gov/pubmed/31871190
http://dx.doi.org/10.1073/pnas.1916398117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955301/
https://www.ncbi.nlm.nih.gov/pubmed/31871190
http://dx.doi.org/10.1073/pnas.1916398117

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