Cargando…
Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme
A robust body of evidence supports the concept that phosphodiesterase 10A (PDE10A) activity in the basal ganglia orchestrates the control of coordinated movement in human subjects. Although human mutations in the PDE10A gene manifest in hyperkinetic movement disorders that phenocopy many features of...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955301/ https://www.ncbi.nlm.nih.gov/pubmed/31871190 http://dx.doi.org/10.1073/pnas.1916398117 |