FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation

In this study, we provide critical evidence that STAT2 stability regulation plays an essential role in melanoma cell proliferation and colony growth. We found that the interaction of FBXW7 and STAT2 induced STAT2 destabilization via a ubiquitination-mediated proteasomal degradation pathway. Notably,...

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Detalles Bibliográficos
Autores principales: Lee, Cheol-Jung, An, Hyun-Jung, Kim, Seung-Min, Yoo, Sun-Mi, Park, Juhee, Lee, Ga-Eun, Kim, Woo-Young, Kim, Dae Joon, Kang, Han Chang, Lee, Joo Young, Lee, Hye Suk, Cho, Sung-Jun, Cho, Yong-Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955312/
https://www.ncbi.nlm.nih.gov/pubmed/31843895
http://dx.doi.org/10.1073/pnas.1909879116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955312/
https://www.ncbi.nlm.nih.gov/pubmed/31843895
http://dx.doi.org/10.1073/pnas.1909879116

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