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A Novel Rheological Method to Assess Drug-Polymer Interactions Regarding Miscibility and Crystallization of Drug in Amorphous Solid Dispersions for Oral Drug Delivery

Solid dispersions provide a key technology to formulate poorly water-soluble drugs, and a main task of early development is appropriate selection of polymer. This study investigates the use of a novel rheology-based approach to evaluate miscibility and interactions of drugs with polymers regarding a...

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Detalles Bibliográficos
Autores principales: Tsakiridou, Georgia, Reppas, Christos, Kuentz, Martin, Kalantzi, Lida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955678/
https://www.ncbi.nlm.nih.gov/pubmed/31766731
http://dx.doi.org/10.3390/pharmaceutics11120625