High Kanamycin Concentration as Another Stress Factor Additional to Temperature to Increase pDNA Production in E. coli DH5α Batch and Fed-Batch Cultures

Plasmid DNA (pDNA) vaccines require high supercoiled-pDNA doses (milligrams) to achieve an adequate immune response. Therefore, processes development to obtain high pDNA yields and productivity is crucial. pDNA production is affected by several factors including culture type, medium composition, and...

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Detalles Bibliográficos
Autores principales: Grijalva-Hernández, Fernando, Vega-Estrada, Jesús, Escobar-Rosales, Montserrat, Ortega-López, Jaime, Aguilar-López, Ricardo, Lara, Alvaro R., Montes-Horcasitas, Ma. del Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955755/
https://www.ncbi.nlm.nih.gov/pubmed/31861108
http://dx.doi.org/10.3390/microorganisms7120711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955755/
https://www.ncbi.nlm.nih.gov/pubmed/31861108
http://dx.doi.org/10.3390/microorganisms7120711

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