PACAP27 mitigates an age‐dependent hippocampal vulnerability to PGJ2‐induced spatial learning deficits and neuroinflammation in mice

BACKGROUND: Inflammation in the brain is mediated by the cyclooxygenase pathway, which leads to the production of prostaglandins. Prostaglandin (PG) D2, the most abundant PG in the brain, increases under pathological conditions and is spontaneously metabolized to PGJ2. PGJ2 is highly neurotoxic, wit...

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Detalles Bibliográficos
Autores principales: Avila, Jorge A., Kiprowska, Magdalena, Jean‐Louis, Teneka, Rockwell, Patricia, Figueiredo‐Pereira, Maria E., Serrano, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955932/
https://www.ncbi.nlm.nih.gov/pubmed/31769222
http://dx.doi.org/10.1002/brb3.1465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955932/
https://www.ncbi.nlm.nih.gov/pubmed/31769222
http://dx.doi.org/10.1002/brb3.1465

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