Development of a Phosphoric Acid-Mediated Hyaluronic Acid Gel Sheet for Efficient Transdermal Delivery of Alendronate for Anti-Osteoporotic Therapy

For efficient transdermal delivery of alendronate (ALN) for anti-osteoporotic therapy, we developed a hyaluronic acid (HA) gel sheet that was prepared simply by enhancing HA noncovalent interactions using phosphoric acid and polyhydric alcohol (propanediol and glycerin). HA solution viscosity increa...

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Detalles Bibliográficos
Autores principales: Naito, Chihiro, Katsumi, Hidemasa, Yoneto, Kunio, Omura, Mao, Nishidono, Mayuko, Kamei, Sachi, Mizoguchi, Akiya, Tamba, Ayaka, Tanaka, Akiko, Morishita, Masaki, Yamamoto, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956090/
https://www.ncbi.nlm.nih.gov/pubmed/31810310
http://dx.doi.org/10.3390/pharmaceutics11120643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956090/
https://www.ncbi.nlm.nih.gov/pubmed/31810310
http://dx.doi.org/10.3390/pharmaceutics11120643

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