Glutamic Acid Increased Methotrexate Polyglutamation and Cytotoxicity in a CCRF-SB Acute Lymphoblastic Leukemia Cell Line

Background and Objectives: Acute lymphoblastic leukemia (ALL) is the most common type of cancer in childhood. The majority of patients respond to treatment, but those with resistant phenotypes suffer relapse or death. The antifolate methotrexate (MTX) is the most commonly used drug against ALL due t...

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Detalles Bibliográficos
Autores principales: Mendoza-Santiago, Alma, Becerra, Edgardo, Garay, Edith, Bah, Moustapha, Berumen-Segura, Laura, Escobar-Cabrera, Jesica, Hernández-Pérez, Abigail, García-Alcocer, Guadalupe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956105/
https://www.ncbi.nlm.nih.gov/pubmed/31779260
http://dx.doi.org/10.3390/medicina55120758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956105/
https://www.ncbi.nlm.nih.gov/pubmed/31779260
http://dx.doi.org/10.3390/medicina55120758

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