Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential

BACKGROUND: CD47, the integrin-related protein, plays an important role in immune resistance and escape of tumor cells. Antibodies blocking the CD47/SIRPα signal pathway can effectively stimulate macrophage-mediated phagocytosis of tumor cells, which becomes a promising approach for tumor immunother...

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Detalles Bibliográficos
Autores principales: Ma, Linlin, Zhu, Min, Gai, Junwei, Li, Guanghui, Chang, Qing, Qiao, Peng, Cao, Longlong, Chen, Wanqing, Zhang, Siyuan, Wan, Yakun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956557/
https://www.ncbi.nlm.nih.gov/pubmed/31931812
http://dx.doi.org/10.1186/s12951-020-0571-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956557/
https://www.ncbi.nlm.nih.gov/pubmed/31931812
http://dx.doi.org/10.1186/s12951-020-0571-2

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