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Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential
BACKGROUND: CD47, the integrin-related protein, plays an important role in immune resistance and escape of tumor cells. Antibodies blocking the CD47/SIRPα signal pathway can effectively stimulate macrophage-mediated phagocytosis of tumor cells, which becomes a promising approach for tumor immunother...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956557/ https://www.ncbi.nlm.nih.gov/pubmed/31931812 http://dx.doi.org/10.1186/s12951-020-0571-2 |