Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy

Reduced expression of the survival motor neuron (SMN) protein causes the neurodegenerative disease spinal muscular atrophy (SMA). Here, we show that adeno-associated virus serotype 9 (AAV9)-mediated delivery of Stasimon—a gene encoding an endoplasmic reticulum (ER)-resident transmembrane protein reg...

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Detalles Bibliográficos
Autores principales: Simon, Christian M., Van Alstyne, Meaghan, Lotti, Francesco, Bianchetti, Elena, Tisdale, Sarah, Watterson, D. Martin, Mentis, George Z., Pellizzoni, Livio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956708/
https://www.ncbi.nlm.nih.gov/pubmed/31851921
http://dx.doi.org/10.1016/j.celrep.2019.11.058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956708/
https://www.ncbi.nlm.nih.gov/pubmed/31851921
http://dx.doi.org/10.1016/j.celrep.2019.11.058

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