Genetic cooperativity in multi-layer networks implicates cell survival and senescence in the striatum of Huntington’s disease mice synchronous to symptoms

MOTIVATION: Huntington’s disease (HD) may evolve through gene deregulation. However, the impact of gene deregulation on the dynamics of genetic cooperativity in HD remains poorly understood. Here, we built a multi-layer network model of temporal dynamics of genetic cooperativity in the brain of HD k...

Descripción completa

Detalles Bibliográficos
Autores principales: Bigan, Erwan, Sasidharan Nair, Satish, Lejeune, François-Xavier, Fragnaud, Hélissande, Parmentier, Frédéric, Mégret, Lucile, Verny, Marc, Aaronson, Jeff, Rosinski, Jim, Neri, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956776/
https://www.ncbi.nlm.nih.gov/pubmed/31228193
http://dx.doi.org/10.1093/bioinformatics/btz514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956776/
https://www.ncbi.nlm.nih.gov/pubmed/31228193
http://dx.doi.org/10.1093/bioinformatics/btz514

Ejemplares similares