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Genetic cooperativity in multi-layer networks implicates cell survival and senescence in the striatum of Huntington’s disease mice synchronous to symptoms

MOTIVATION: Huntington’s disease (HD) may evolve through gene deregulation. However, the impact of gene deregulation on the dynamics of genetic cooperativity in HD remains poorly understood. Here, we built a multi-layer network model of temporal dynamics of genetic cooperativity in the brain of HD k...

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Detalles Bibliográficos
Autores principales:	Bigan, Erwan, Sasidharan Nair, Satish, Lejeune, François-Xavier, Fragnaud, Hélissande, Parmentier, Frédéric, Mégret, Lucile, Verny, Marc, Aaronson, Jeff, Rosinski, Jim, Neri, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956776/ https://www.ncbi.nlm.nih.gov/pubmed/31228193 http://dx.doi.org/10.1093/bioinformatics/btz514

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