Denervation drives skeletal muscle atrophy and induces mitochondrial dysfunction, mitophagy and apoptosis via miR-142a-5p/MFN1 axis

Rationale: Peripheral nerve injury is common in clinic, which leads to severe atrophy and dysfunction of the denervated muscles, but the underlying mechanism is not fully understood. Recent studies advanced the causative role of mitochondrial dysfunction in muscle atrophy, while the upstream trigger...

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Detalles Bibliográficos
Autores principales: Yang, Xiaofan, Xue, Pingping, Chen, Hongrui, Yuan, Meng, Kang, Yu, Duscher, Dominik, Machens, Hans-Günther, Chen, Zhenbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956801/
https://www.ncbi.nlm.nih.gov/pubmed/31938072
http://dx.doi.org/10.7150/thno.40857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956801/
https://www.ncbi.nlm.nih.gov/pubmed/31938072
http://dx.doi.org/10.7150/thno.40857

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