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Fructose-1,6-bisphosphatase loss modulates STAT3-dependent expression of PD-L1 and cancer immunity

Rationale: Abnormal expression of programmed death-1 (PD-1) ligand-1(PD-L1) in cancer cells plays a crucial role in cancer immune evasion and progression. The immune checkpoint molecules PD-1 and PD-L1 have been targeted for cancer treatment with significant benefits for cancer patients. However, th...

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Detalles Bibliográficos
Autores principales: Wang, Bo, Zhou, Yingke, Zhang, Jun, Jin, Xin, Wu, Heshui, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956820/
https://www.ncbi.nlm.nih.gov/pubmed/31938049
http://dx.doi.org/10.7150/thno.38137