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A bipartite structural organization defines the SERINC family of HIV-1 restriction factors
The human integral membrane protein SERINC5 potently restricts HIV-1 infectivity and sensitises the virus to antibody-mediated neutralisation. Here, using cryo-electron microscopy, we determined the structures of human SERINC5 and its ortholog from Drosophila melanogaster at sub-nm and near-atomic r...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956856/ https://www.ncbi.nlm.nih.gov/pubmed/31907454 http://dx.doi.org/10.1038/s41594-019-0357-0 |