A bipartite structural organization defines the SERINC family of HIV-1 restriction factors

The human integral membrane protein SERINC5 potently restricts HIV-1 infectivity and sensitises the virus to antibody-mediated neutralisation. Here, using cryo-electron microscopy, we determined the structures of human SERINC5 and its ortholog from Drosophila melanogaster at sub-nm and near-atomic r...

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Detalles Bibliográficos
Autores principales: Pye, Valerie E., Rosa, Annachiara, Bertelli, Cinzia, Struwe, Weston B., Maslen, Sarah L., Corey, Robin, Liko, Idlir, Hassall, Mark, Mattiuzzo, Giada, Ballandras-Colas, Allison, Nans, Andrea, Takeuchi, Yasuhiro, Stansfeld, Phillip J., Skehel, J. Mark, Robinson, Carol V., Pizzato, Massimo, Cherepanov, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956856/
https://www.ncbi.nlm.nih.gov/pubmed/31907454
http://dx.doi.org/10.1038/s41594-019-0357-0

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