CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4

The mammalian Pcdhg gene cluster encodes a family of 22 cell adhesion molecules, the gamma-Protocadherins (γ-Pcdhs), critical for neuronal survival and neural circuit formation. The extent to which isoform diversity–a γ-Pcdh hallmark–is required for their functions remains unclear. We used a CRISPR/...

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Detalles Bibliográficos
Autores principales: Garrett, Andrew M., Bosch, Peter J., Steffen, David M., Fuller, Leah C., Marcucci, Charles G., Koch, Alexis A., Bais, Preeti, Weiner, Joshua A., Burgess, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957209/
https://www.ncbi.nlm.nih.gov/pubmed/31877124
http://dx.doi.org/10.1371/journal.pgen.1008554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957209/
https://www.ncbi.nlm.nih.gov/pubmed/31877124
http://dx.doi.org/10.1371/journal.pgen.1008554

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