Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological diseases including Parkinson’s disease (PD). Previously, we reported the structure of alpha-synuclein fibrils (residues 1–121), composed of two protofibrils that are connected via a densely-packed interface...

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Detalles Bibliográficos
Autores principales: Guerrero-Ferreira, Ricardo, Taylor, Nicholas MI, Arteni, Ana-Andreea, Kumari, Pratibha, Mona, Daniel, Ringler, Philippe, Britschgi, Markus, Lauer, Matthias E, Makky, Ali, Verasdonck, Joeri, Riek, Roland, Melki, Ronald, Meier, Beat H, Böckmann, Anja, Bousset, Luc, Stahlberg, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957273/
https://www.ncbi.nlm.nih.gov/pubmed/31815671
http://dx.doi.org/10.7554/eLife.48907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957273/
https://www.ncbi.nlm.nih.gov/pubmed/31815671
http://dx.doi.org/10.7554/eLife.48907

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