Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho

Klotho is an age-extending, cognition-enhancing protein found to be down-regulated in aged mammals when age-related diseases start to appear. Low levels of Klotho occur in neurodegenerative diseases, kidney disease and many cancers. Many normal and pathologic processes involve the proteolytic sheddi...

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Detalles Bibliográficos
Autores principales: Chen, Ci-Di, Li, Yuexuan, Chen, Arthur K., Rudy, Melissa A., Nasse, Jason S., Zeldich, Ella, Polanco, Taryn J., Abraham, Carmela R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957300/
https://www.ncbi.nlm.nih.gov/pubmed/31929539
http://dx.doi.org/10.1371/journal.pone.0226382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957300/
https://www.ncbi.nlm.nih.gov/pubmed/31929539
http://dx.doi.org/10.1371/journal.pone.0226382

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