MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin interactions

Methyl-CpG-binding-Protein 2 (MeCP2) is an abundant nuclear protein highly enriched in neurons. Here we report live-cell single-molecule imaging studies of the kinetic features of mouse MeCP2 at high spatial-temporal resolution. MeCP2 displays dynamic features that are distinct from both highly mobi...

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Detalles Bibliográficos
Autores principales: Piccolo, Francesco M, Liu, Zhe, Dong, Peng, Hsu, Ching-Lung, Stoyanova, Elitsa I, Rao, Anjana, Tjian, Robert, Heintz, Nathaniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957317/
https://www.ncbi.nlm.nih.gov/pubmed/31868585
http://dx.doi.org/10.7554/eLife.51449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957317/
https://www.ncbi.nlm.nih.gov/pubmed/31868585
http://dx.doi.org/10.7554/eLife.51449

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