Distinct DNA repair pathways cause genomic instability at alternative DNA structures

Alternative DNA structure-forming sequences can stimulate mutagenesis and are enriched at mutation hotspots in human cancer genomes, implicating them in disease etiology. However, the mechanisms involved are not well characterized. Here, we discover that Z-DNA is mutagenic in yeast as well as human...

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Detalles Bibliográficos
Autores principales: McKinney, Jennifer A., Wang, Guliang, Mukherjee, Anirban, Christensen, Laura, Subramanian, Sai H. Sankara, Zhao, Junhua, Vasquez, Karen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957503/
https://www.ncbi.nlm.nih.gov/pubmed/31932649
http://dx.doi.org/10.1038/s41467-019-13878-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957503/
https://www.ncbi.nlm.nih.gov/pubmed/31932649
http://dx.doi.org/10.1038/s41467-019-13878-9

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