Endogenous MicroRNA Competition as a Mechanism of shRNA-Induced Cardiotoxicity

Gene knockdown using short hairpin RNAs (shRNAs) is a promising strategy for targeting dominant mutations; however, delivering too much shRNA can disrupt the processing of endogenous microRNAs (miRNAs) and lead to toxicity. Here, we sought to understand the effect that excessive shRNAs have on muscl...

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Detalles Bibliográficos
Autores principales: Course, Meredith M., Gudsnuk, Kathryn, Desai, Nitin, Chamberlain, Joel R., Valdmanis, Paul N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957822/
https://www.ncbi.nlm.nih.gov/pubmed/31927330
http://dx.doi.org/10.1016/j.omtn.2019.12.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957822/
https://www.ncbi.nlm.nih.gov/pubmed/31927330
http://dx.doi.org/10.1016/j.omtn.2019.12.007

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