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Endogenous MicroRNA Competition as a Mechanism of shRNA-Induced Cardiotoxicity
Gene knockdown using short hairpin RNAs (shRNAs) is a promising strategy for targeting dominant mutations; however, delivering too much shRNA can disrupt the processing of endogenous microRNAs (miRNAs) and lead to toxicity. Here, we sought to understand the effect that excessive shRNAs have on muscl...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957822/ https://www.ncbi.nlm.nih.gov/pubmed/31927330 http://dx.doi.org/10.1016/j.omtn.2019.12.007 |