Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus

Lurasidone is an atypical mood-stabilizing antipsychotic agent with unique receptor-binding profile, including 5-HT7 receptor (5-HT7R) antagonism. Effects of 5-HT7R antagonism on transmitter systems of schizophrenia and mood disorders, however, have not been well clarified. Thus, this study examined...

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Detalles Bibliográficos
Autores principales: Okada, Motohiro, Fukuyama, Kouji, Okubo, Ruri, Shiroyama, Takashi, Ueda, Yuto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958501/
https://www.ncbi.nlm.nih.gov/pubmed/31590422
http://dx.doi.org/10.3390/ph12040149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958501/
https://www.ncbi.nlm.nih.gov/pubmed/31590422
http://dx.doi.org/10.3390/ph12040149

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