Metabolism and Pharmacokinetic Study of the Boron-Containing Prodrug of Belinostat (ZL277), a Pan HDAC Inhibitor with Enhanced Bioavailability

ZL277 is a prodrug of belinostat with enhanced bioavailability and efficacy as a pan histone deacetylase (HDAC) inhibitor. In this study, we investigated the metabolism and pharmacokinetics of ZL277 in liver S9 fractions, liver microsomes, liver cytosol, and in mice. Metabolic products were identifi...

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Detalles Bibliográficos
Autores principales: Zhang, Changde, Guo, Shanchun, Zhong, Qiu, Zhang, Qiang, Hossain, Ahamed, Zheng, Shilong, Wang, Guangdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958523/
https://www.ncbi.nlm.nih.gov/pubmed/31817969
http://dx.doi.org/10.3390/ph12040180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958523/
https://www.ncbi.nlm.nih.gov/pubmed/31817969
http://dx.doi.org/10.3390/ph12040180

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