Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles

Studies on the substrate selectivity of recombinant ferrous-iron- and 2-oxoglutarate-dependent proline hydroxylases (PHs) reveal that they can catalyse the production of dihydroxylated 5-, 6-, and 7-membered ring products, and can accept bicyclic substrates. Ring-substituted substrate analogues (suc...

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Detalles Bibliográficos
Autores principales: Smart, Tristan J., Hamed, Refaat B., Claridge, Timothy D.W., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958525/
https://www.ncbi.nlm.nih.gov/pubmed/31706681
http://dx.doi.org/10.1016/j.bioorg.2019.103386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958525/
https://www.ncbi.nlm.nih.gov/pubmed/31706681
http://dx.doi.org/10.1016/j.bioorg.2019.103386

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