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Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting

Repeated exposure to pathogens or their antigens triggers anamnestic antibody responses that are higher in magnitude and affinity than the primary response. These involve reengagement of memory B cell (MBC) clones, the diversity and specificity of which determine the breadth and effectiveness of the...

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Detalles Bibliográficos
Autores principales: Mesin, Luka, Schiepers, Ariën, Ersching, Jonatan, Barbulescu, Alexandru, Cavazzoni, Cecília B., Angelini, Alessandro, Okada, Takaharu, Kurosaki, Tomohiro, Victora, Gabriel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958527/
https://www.ncbi.nlm.nih.gov/pubmed/31866068
http://dx.doi.org/10.1016/j.cell.2019.11.032