Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage

BACKGROUND: Mounting evidence points to a crucial role of amyloid-β (Aβ) in the pathophysiology of Alzheimer’s disease (AD), a disorder in which brain glucose hypometabolism, downregulation of central elements of phosphorylation pathways, reduced ATP levels, and enhanced oxidative damage coexist, an...

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Detalles Bibliográficos
Autores principales: Sotolongo, Krystal, Ghiso, Jorge, Rostagno, Agueda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958642/
https://www.ncbi.nlm.nih.gov/pubmed/31931869
http://dx.doi.org/10.1186/s13195-019-0578-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958642/
https://www.ncbi.nlm.nih.gov/pubmed/31931869
http://dx.doi.org/10.1186/s13195-019-0578-9

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