Cargando…

C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts

BACKGROUND: Mounting evidence suggests that complement components promote tumor progression via modulating immune suppression, angiogenesis, or tumor cell proliferation. However, the role of C3a-C3aR signaling in regulating lung metastasis of breast cancer remains unknown. METHODS: We performed vari...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shu, Chi, Zha, Haoran, Long, Haixia, Wang, Xinxin, Yang, Fei, Gao, Jianbao, Hu, Chunyan, Zhou, Li, Guo, Bo, Zhu, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958674/ https://www.ncbi.nlm.nih.gov/pubmed/31931851 http://dx.doi.org/10.1186/s13046-019-1515-2

Ejemplares similares

Centromere protein U expression promotes non-small-cell lung cancer cell proliferation through FOXM1 and predicts poor survival
por: Wang, Xinxin, et al.
Publicado: (2018)

C3aR and C5aR1 act as key regulators of human and mouse β-cell function
por: Atanes, Patricio, et al.
Publicado: (2017)

C3a-C3aR signaling is a novel modulator of skeletal homeostasis
por: Kuhn, Megan B., et al.
Publicado: (2023)

Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections
por: Muenstermann, Marcel, et al.
Publicado: (2019)

The “C3aR Antagonist” SB290157 is a Partial C5aR2 Agonist
por: Li, Xaria X., et al.
Publicado: (2021)

Down-Regulation of C3aR/C5aR Inhibits Cell Proliferation and EMT in Hepatocellular Carcinoma
por: Chen, Bendong, et al.
Publicado: (2020)

DEFECTIVE ENGRAFTMENT OF C3aR(-/-) HEMATOPOIETIC STEM PROGENITOR CELLS REVEALS A NOVEL ROLE OF THE C3a-C3aR AXIS IN BONE MARROW HOMING
por: Wysoczynski, Marcin, et al.
Publicado: (2009)

Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome
por: McCullough, Rebecca L., et al.
Publicado: (2018)

The Complement Receptors C3aR and C5aR Are a New Class of Immune Checkpoint Receptor in Cancer Immunotherapy
por: Wang, Yu, et al.
Publicado: (2019)

C3a Enhances the Formation of Intestinal Organoids through C3aR1
por: Matsumoto, Naoya, et al.
Publicado: (2017)

Cytotoxic chemotherapy reduces T cell trafficking to the spleen by downregulating the expression of C-C motif chemokine ligand 21 and C-C motif chemokine ligand 19
por: Liu, Lina, et al.
Publicado: (2018)

Downregulation of Complement C3 and C3aR Expression in Subcutaneous Adipose Tissue in Obese Women
por: Gupta, Abhishek, et al.
Publicado: (2014)

Astrocyte-microglia interaction through C3/C3aR pathway modulates neuropathic pain in rats model of chronic constriction injury
por: Mou, Wanying, et al.
Publicado: (2022)

C3aR signaling and gliosis in response to neurodevelopmental damage in the cerebellum
por: Young, Kevin G., et al.
Publicado: (2019)

The complement C3a-C3aR and C5a-C5aR pathways promote viability and inflammation of human retinal pigment epithelium cells by targeting NF-κB signaling
por: Luo, Shasha, et al.
Publicado: (2022)

Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
por: Carvalho, Klebea, et al.
Publicado: (2022)

Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors
por: Colley, Caroline S., et al.
Publicado: (2017)

Stroma-derived Fibrinogen-like Protein 2 Activates Cancer-associated Fibroblasts to Promote Tumor Growth in Lung Cancer
por: Zhu, Ying, et al.
Publicado: (2017)

Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion
por: Zhang, Lin-Yuan, et al.
Publicado: (2020)

Complement C3a Enhances the Phagocytic Activity of B Cells Through C3aR in a Fish
por: Ma, Zi-You, et al.
Publicado: (2022)

Correction to: C3aR signaling and gliosis in response to neurodevelopmental damage in the cerebellum
por: Young, Kevin G., et al.
Publicado: (2020)

C3aR plays both sides in regulating resistance to bacterial infections
por: Corcoran, Jesse A., et al.
Publicado: (2022)

Insights into the Complement System of Tunicates: C3a/C5aR of the Colonial Ascidian Botryllus schlosseri
por: Peronato, Anna, et al.
Publicado: (2020)

Pan-Cancer Analysis of Immune Complement Signature C3/C5/C3AR1/C5AR1 in Association with Tumor Immune Evasion and Therapy Resistance
por: Lawal, Bashir, et al.
Publicado: (2021)

C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation
por: Ding, Peipei, et al.
Publicado: (2020)

IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression
por: Zhang, Man-Man, et al.
Publicado: (2022)

T lymphocytes maintain structure and function of fibroblastic reticular cells via lymphotoxin (LT)-B
por: Zhao, Lintao, et al.
Publicado: (2014)

Helicobacter pylori‐derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3‐C3aR signalling
por: Xie, Junhua, et al.
Publicado: (2023)

Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte–microglia C3-C3aR pathway
por: Zhang, Wenlong, et al.
Publicado: (2023)

(3R,3aR,6R,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diyl dibenzoate
por: Piccialli, Vincenzo, et al.
Publicado: (2013)

Mechanism of activation and biased signaling in complement receptor C5aR1
por: Feng, Yuying, et al.
Publicado: (2023)

Complement component C3aR constitutes a novel regulator for chick eye morphogenesis
por: Grajales-Esquivel, Erika, et al.
Publicado: (2017)

Complement Activation and Up-Regulated Expression of Anaphylatoxin C3a/C3aR in Glioblastoma: Deciphering the Links with TGF-β and VEGF
por: Ah-Pine, Franck, et al.
Publicado: (2023)

Arrestins function in cAR1 GPCR-mediated signaling and cAR1 internalization in the development of Dictyostelium discoideum
por: Cao, Xiumei, et al.
Publicado: (2014)

C5a and C5aR are elevated in joints of rheumatoid and psoriatic arthritis patients, and C5aR blockade attenuates leukocyte migration to synovial fluid
por: Hornum, Lars, et al.
Publicado: (2017)

Apigenin inhibits C5a-induced proliferation of human nasopharyngeal carcinoma cells through down-regulation of C5aR
por: Zhang, Yanshu, et al.
Publicado: (2018)

The Complement Anaphylatoxin C3a Receptor (C3aR) Contributes to the Inflammatory Response in Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice
por: Wende, Elisabeth, et al.
Publicado: (2013)

Sustained activation of C3aR in a human podocyte line impairs the morphological maturation of the cells
por: Zheng, Jing-Min, et al.
Publicado: (2020)

TLQP-21 is a low potency partial C3aR activator on human primary macrophages
por: Li, Xaria X., et al.
Publicado: (2023)

CD63 and C3AR1: The Potential Molecular Targets in the Progression of Septic Shock
por: Yu, Ning, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_15deaijghhs271nva3jv20t8ap