Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data

BACKGROUND: The use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation has greatly increased. However, data regarding the clinical outcomes of this approach are lacking. The objective of this multicenter prospective observational cohort study was to evaluate lung trans...

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Autores principales: Ko, Ryoung-Eun, Lee, Jin Gu, Kim, Song Yee, Kim, Young Tae, Choi, Sun Mi, Kim, Do Hyung, Cho, Woo Hyun, Park, Seung-Il, Jo, Kyung-Wook, Kim, Hong Kwan, Paik, Hyo Chae, Jeon, Kyeongman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958687/
https://www.ncbi.nlm.nih.gov/pubmed/31931798
http://dx.doi.org/10.1186/s12931-020-1289-2
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author Ko, Ryoung-Eun
Lee, Jin Gu
Kim, Song Yee
Kim, Young Tae
Choi, Sun Mi
Kim, Do Hyung
Cho, Woo Hyun
Park, Seung-Il
Jo, Kyung-Wook
Kim, Hong Kwan
Paik, Hyo Chae
Jeon, Kyeongman
author_facet Ko, Ryoung-Eun
Lee, Jin Gu
Kim, Song Yee
Kim, Young Tae
Choi, Sun Mi
Kim, Do Hyung
Cho, Woo Hyun
Park, Seung-Il
Jo, Kyung-Wook
Kim, Hong Kwan
Paik, Hyo Chae
Jeon, Kyeongman
author_sort Ko, Ryoung-Eun
collection PubMed
description BACKGROUND: The use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation has greatly increased. However, data regarding the clinical outcomes of this approach are lacking. The objective of this multicenter prospective observational cohort study was to evaluate lung transplantation outcomes in Korean Organ Transplantation Registry (KOTRY) patients for whom ECMO was used as a bridge to transplantation. METHODS: Between March 2015 and December 2017, a total of 112 patients received lung transplantation and were registered in the KOTRY, which is a prospective, multicenter cohort registry. The entire cohort was divided into two groups: the control group (n = 85, 75.9%) and bridge-ECMO group (n = 27, 24.1%). RESULTS: There were no significant differences in pre-transplant and intraoperative characteristics except for poorer oxygenation, more ventilator use, and longer operation time in the bridge-ECMO group. The prevalence of primary graft dysfunction at 0, 24, 48, and 72 h after transplantation did not differ between the two groups. Although postoperative hospital stays were longer in the bridge-ECMO group than in the control group, hospital mortality did not differ between the two groups (25.9% vs. 13.3%, P = 0.212). The majority of patients (70.4% of the bridge-ECMO group and 77.6% of the control group) were discharged directly to their homes. Finally, the use of ECMO as a bridge to lung transplantation did not significantly affect overall survival and graft function. CONCLUSIONS: Short- and long-term post-transplant outcomes of bridge-ECMO patients were comparable to recipients who did not receive ECMO.
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spelling pubmed-69586872020-01-17 Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data Ko, Ryoung-Eun Lee, Jin Gu Kim, Song Yee Kim, Young Tae Choi, Sun Mi Kim, Do Hyung Cho, Woo Hyun Park, Seung-Il Jo, Kyung-Wook Kim, Hong Kwan Paik, Hyo Chae Jeon, Kyeongman Respir Res Research BACKGROUND: The use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation has greatly increased. However, data regarding the clinical outcomes of this approach are lacking. The objective of this multicenter prospective observational cohort study was to evaluate lung transplantation outcomes in Korean Organ Transplantation Registry (KOTRY) patients for whom ECMO was used as a bridge to transplantation. METHODS: Between March 2015 and December 2017, a total of 112 patients received lung transplantation and were registered in the KOTRY, which is a prospective, multicenter cohort registry. The entire cohort was divided into two groups: the control group (n = 85, 75.9%) and bridge-ECMO group (n = 27, 24.1%). RESULTS: There were no significant differences in pre-transplant and intraoperative characteristics except for poorer oxygenation, more ventilator use, and longer operation time in the bridge-ECMO group. The prevalence of primary graft dysfunction at 0, 24, 48, and 72 h after transplantation did not differ between the two groups. Although postoperative hospital stays were longer in the bridge-ECMO group than in the control group, hospital mortality did not differ between the two groups (25.9% vs. 13.3%, P = 0.212). The majority of patients (70.4% of the bridge-ECMO group and 77.6% of the control group) were discharged directly to their homes. Finally, the use of ECMO as a bridge to lung transplantation did not significantly affect overall survival and graft function. CONCLUSIONS: Short- and long-term post-transplant outcomes of bridge-ECMO patients were comparable to recipients who did not receive ECMO. BioMed Central 2020-01-13 2020 /pmc/articles/PMC6958687/ /pubmed/31931798 http://dx.doi.org/10.1186/s12931-020-1289-2 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Ko, Ryoung-Eun
Lee, Jin Gu
Kim, Song Yee
Kim, Young Tae
Choi, Sun Mi
Kim, Do Hyung
Cho, Woo Hyun
Park, Seung-Il
Jo, Kyung-Wook
Kim, Hong Kwan
Paik, Hyo Chae
Jeon, Kyeongman
Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data
title Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data
title_full Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data
title_fullStr Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data
title_full_unstemmed Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data
title_short Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data
title_sort extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of korean organ transplantation registry (kotry) data
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958687/
https://www.ncbi.nlm.nih.gov/pubmed/31931798
http://dx.doi.org/10.1186/s12931-020-1289-2
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