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Platelet HIF-2α promotes thrombogenicity through PAI-1 synthesis and extracellular vesicle release
Oxygen-compromised environments, such as high altitude, are associated with platelet hyperactivity. Platelets confined within the relatively impervious core of an aggregate/thrombus have restricted access to oxygen, yet they continue to perform energy-intensive procoagulant activities that sustain t...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Ferrata Storti Foundation
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959171/ https://www.ncbi.nlm.nih.gov/pubmed/31004026 http://dx.doi.org/10.3324/haematol.2019.217463 |