Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human adult erythroid cells

As high fetal hemoglobin levels ameliorate the underlying pathophysiological defects in sickle cell anemia and beta (β)-thalassemia, understanding the mechanisms that enforce silencing of fetal hemoglobin postnatally offers the promise of effective molecular therapy. Depletion of the Nucleosome Remo...

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Detalles Bibliográficos
Autores principales: Yu, Xiaofei, Azzo, Alexander, Bilinovich, Stephanie M., Li, Xia, Dozmorov, Mikhail, Kurita, Ryo, Nakamura, Yukio, Williams, David C., Ginder, Gordon D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959176/
https://www.ncbi.nlm.nih.gov/pubmed/31004025
http://dx.doi.org/10.3324/haematol.2018.210963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959176/
https://www.ncbi.nlm.nih.gov/pubmed/31004025
http://dx.doi.org/10.3324/haematol.2018.210963

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