FLT3-ITD cooperates with Rac1 to modulate the sensitivity of leukemic cells to chemotherapeutic agents via regulation of DNA repair pathways

Acute myeloid leukemia (AML) is an aggressive hematologic neoplasm, and patients with an internal tandem duplication (ITD) mutation of the FMS-like tyrosine kinase-3 (FLT3) receptor gene have a poor prognosis. FLT3-ITD interacts with DOCK2, a G effector protein that activates Rac1/2. Previously, we...

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Detalles Bibliográficos
Autores principales: Wu, Min, Li, Li, Hamaker, Max, Small, Donald, Duffield, Amy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959181/
https://www.ncbi.nlm.nih.gov/pubmed/30975911
http://dx.doi.org/10.3324/haematol.2018.208843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959181/
https://www.ncbi.nlm.nih.gov/pubmed/30975911
http://dx.doi.org/10.3324/haematol.2018.208843

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