Glycofullerenes as non-receptor tyrosine kinase inhibitors- towards better nanotherapeutics for pancreatic cancer treatment

The water-soluble glycofullerenes GF1 and GF2 were synthesized using two-step modified Bingel-Hirsch methodology. Interestingly, we identified buckyballs as a novel class of non-receptor Src kinases inhibitors. The evaluated compounds were found to inhibit Fyn A and BTK proteins with IC(50) values i...

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Detalles Bibliográficos
Autores principales: Serda, Maciej, Malarz, Katarzyna, Mrozek-Wilczkiewicz, Anna, Wojtyniak, Marcin, Musioł, Robert, Curley, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959220/
https://www.ncbi.nlm.nih.gov/pubmed/31937861
http://dx.doi.org/10.1038/s41598-019-57155-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959220/
https://www.ncbi.nlm.nih.gov/pubmed/31937861
http://dx.doi.org/10.1038/s41598-019-57155-7

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