The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State

The aggregation of α-synuclein (αS), a protein abundant at presynaptic terminals, is associated with a range of highly debilitating neurodegenerative conditions, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Emerging evidence indicates that th...

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Detalles Bibliográficos
Autores principales: Runfola, Matteo, De Simone, Alfonso, Vendruscolo, Michele, Dobson, Christopher M., Fusco, Giuliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959233/
https://www.ncbi.nlm.nih.gov/pubmed/31937832
http://dx.doi.org/10.1038/s41598-019-57023-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959233/
https://www.ncbi.nlm.nih.gov/pubmed/31937832
http://dx.doi.org/10.1038/s41598-019-57023-4

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