Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance

BET bromodomain inhibitors (BETi), such as JQ1, have been demonstrated to effectively kill multiple types of cancer cells. However, the underlying mechanisms for BETi resistance remain largely unknown. Our evidences show that JQ1 treatment evicts BRD4 from the FOXD3-localized MIR548D1 gene promoter,...

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Detalles Bibliográficos
Autores principales: Tai, Fang, Gong, Kunxiang, Song, Kai, He, Yanling, Shi, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959298/
https://www.ncbi.nlm.nih.gov/pubmed/31937753
http://dx.doi.org/10.1038/s41467-019-14083-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959298/
https://www.ncbi.nlm.nih.gov/pubmed/31937753
http://dx.doi.org/10.1038/s41467-019-14083-4

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