Unspecific DNA recombination in AdipoqCre-ER(T2) – mediated knockout approaches in transgenic mice is sex-, age- and genotype-dependent

Due to the epidemic rise of obesity prevalence, adipose tissue (AT) research is of major interest. Our aim was to study specificity of the most-common Cre/loxP approach for inducible gene manipulation of AT in mice (AdipoqCre-ER(T2)). We used mice with tamoxifen-sensitive Cre recombinase controlled...

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Detalles Bibliográficos
Autores principales: Lindhorst, Andreas, Bechmann, Ingo, Gericke, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959310/
https://www.ncbi.nlm.nih.gov/pubmed/31842670
http://dx.doi.org/10.1080/21623945.2019.1701394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959310/
https://www.ncbi.nlm.nih.gov/pubmed/31842670
http://dx.doi.org/10.1080/21623945.2019.1701394

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