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Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured sensory neurons in dorsal root ganglia (DRG). Here we demonstrate a critical contribution of DRG macrophages, but not those at the nerve injury...

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Detalles Bibliográficos
Autores principales: Yu, Xiaobing, Liu, Hongju, Hamel, Katherine A., Morvan, Maelig G., Yu, Stephen, Leff, Jacqueline, Guan, Zhonghui, Braz, Joao M., Basbaum, Allan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959328/
https://www.ncbi.nlm.nih.gov/pubmed/31937758
http://dx.doi.org/10.1038/s41467-019-13839-2