Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but this has not been tested directly in vivo.  Here, we investigated synaptic vesicle glycoprotein 2A (SV2A) levels and their relationship to symptoms and structural brain measures using [(11)C]UCB-J positron emi...

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Detalles Bibliográficos
Autores principales: Onwordi, Ellis Chika, Halff, Els F., Whitehurst, Thomas, Mansur, Ayla, Cotel, Marie-Caroline, Wells, Lisa, Creeney, Hannah, Bonsall, David, Rogdaki, Maria, Shatalina, Ekaterina, Reis Marques, Tiago, Rabiner, Eugenii A., Gunn, Roger N., Natesan, Sridhar, Vernon, Anthony C., Howes, Oliver D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959348/
https://www.ncbi.nlm.nih.gov/pubmed/31937764
http://dx.doi.org/10.1038/s41467-019-14122-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959348/
https://www.ncbi.nlm.nih.gov/pubmed/31937764
http://dx.doi.org/10.1038/s41467-019-14122-0

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