Cargando…

Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but this has not been tested directly in vivo. Here, we investigated synaptic vesicle glycoprotein 2A (SV2A) levels and their relationship to symptoms and structural brain measures using [(11)C]UCB-J positron emi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Onwordi, Ellis Chika, Halff, Els F., Whitehurst, Thomas, Mansur, Ayla, Cotel, Marie-Caroline, Wells, Lisa, Creeney, Hannah, Bonsall, David, Rogdaki, Maria, Shatalina, Ekaterina, Reis Marques, Tiago, Rabiner, Eugenii A., Gunn, Roger N., Natesan, Sridhar, Vernon, Anthony C., Howes, Oliver D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959348/ https://www.ncbi.nlm.nih.gov/pubmed/31937764 http://dx.doi.org/10.1038/s41467-019-14122-0

Ejemplares similares

O11.3. SYNAPTIC MARKER PROTEIN SV2A IS REDUCED IN SCHIZOPHRENIA IN VIVO AND UNAFFECTED BY ANTIPSYCHOTICS IN RATS
por: Chika Onwordi, Ellis, et al.
Publicado: (2020)

The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study
por: Onwordi, Ellis Chika, et al.
Publicado: (2021)

O5.5. THE NEUROBIOLOGY OF NEGATIVE SYMPTOMS IN SCHIZOPHRENIA: MULTI-MODAL PET AND FMRI FINDINGS
por: Howes, Oliver, et al.
Publicado: (2020)

The histamine system and cognitive function: An in vivo H3 receptor PET imaging study in healthy volunteers and patients with schizophrenia
por: Arumuham, Atheeshaan, et al.
Publicado: (2023)

40.3 MATERNAL IMMUNE ACTIVATION AND CHRONIC HALOPERIDOL INTERACT TO INCREASE MICROGLIAL ACTIVATION IN VIVO: DO ANTIPSYCHOTICS INFLAME THE BRAIN?
por: Cotel, Marie-Caroline, et al.
Publicado: (2018)

Adenosine A(2A) receptor in schizophrenia: an in vivo brain PET imaging study
por: Marques, Tiago Reis, et al.
Publicado: (2021)

T193. CHRONIC HALOPERIDOL TREATMENT INDUCES SIGNIFICANT CHANGES IN MICROGLIA AND IN THE EXPRESSION OF THE 18 KDA TRANSLOCATOR PROTEIN TSPO IN NAIVE ADULT RAT BRAINS
por: Cotel, Marie, et al.
Publicado: (2018)

Reward processing in schizophrenia and its relation to Mu opioid receptor availability and negative symptoms: A [(11)C]-carfentanil PET and fMRI study
por: Shatalina, Ekaterina, et al.
Publicado: (2023)

The synaptic hypothesis of schizophrenia version III: a master mechanism
por: Howes, Oliver D., et al.
Publicado: (2023)

Evaluation of Intraperitoneal [(18)F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity
por: Halff, Els F., et al.
Publicado: (2022)

The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study
por: Jauhar, Sameer, et al.
Publicado: (2019)

Comparative Effects of Antipsychotics on Metabolic and Endocrine Function in Children and Young People With Schizophrenia: A Systematic Review and Network Meta-Analysis
por: Rogdaki, Maria, et al.
Publicado: (2023)

Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development
por: McCluskey, Stuart P., et al.
Publicado: (2019)

Effect of chronic antipsychotic treatment on striatal phosphodiesterase 10A levels: a [(11)C]MP-10 PET rodent imaging study with ex vivo confirmation
por: Natesan, S, et al.
Publicado: (2014)

Antipsychotic plasma levels in the assessment of poor treatment response in schizophrenia
por: McCutcheon, R., et al.
Publicado: (2017)

Reduced mu opioid receptor availability in schizophrenia revealed with [(11)C]-carfentanil positron emission tomographic Imaging
por: Ashok, Abhishekh H., et al.
Publicado: (2019)

Correction: Regulation of dopaminergic function: an [(18)F]-DOPA PET apomorphine challenge study in humans
por: Jauhar, S., et al.
Publicado: (2018)

Correction: Regulation of dopaminergic function: An [(18)F]-DOPA PET apomorphine challenge study in humans
por: Jauhar, S, et al.
Publicado: (2019)

Regulation of dopaminergic function: an [(18)F]-DOPA PET apomorphine challenge study in humans.
por: Jauhar, S, et al.
Publicado: (2017)

Identifying improved TSPO PET imaging probes through biomathematics: The impact of multiple TSPO binding sites in vivo
por: Guo, Qi, et al.
Publicado: (2012)

Specific and non-specific binding of a tracer for the translocator-specific protein in schizophrenia: an [11C]-PBR28 blocking study
por: Marques, Tiago Reis, et al.
Publicado: (2021)

Endogenous dopamine release in the human brain as a pharmacodynamic biomarker: evaluation of the new GPR139 agonist TAK-041 with [(11)C]PHNO PET
por: Rabiner, Eugenii A., et al.
Publicado: (2021)

A Method for Tapering Antipsychotic Treatment That May Minimize the Risk of Relapse
por: Horowitz, Mark Abie, et al.
Publicado: (2021)

Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes
por: Howes, Oliver D., et al.
Publicado: (2022)

Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis
por: Pillinger, Toby, et al.
Publicado: (2020)

Unaffected in Cambodia
por: Marya, A.
Publicado: (2020)

Acute acetate administration increases endogenous opioid levels in the human brain: A [(11)C]carfentanil molecular imaging study
por: Ashok, Abhishekh H, et al.
Publicado: (2021)

Novel PET Biomarkers to Disentangle Molecular Pathways across Age-Related Neurodegenerative Diseases
por: Wilson, Heather, et al.
Publicado: (2020)

The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment
por: Jauhar, Sameer, et al.
Publicado: (2023)

Cardiac structure and function in patients with schizophrenia taking antipsychotic drugs: an MRI study
por: Pillinger, Toby, et al.
Publicado: (2019)

Chronic exposure to haloperidol and olanzapine leads to common and divergent shape changes in the rat hippocampus in the absence of grey-matter volume loss
por: Crum, W. R., et al.
Publicado: (2016)

The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A (1)H-MRS study in first-episode psychosis patients
por: Zahid, Uzma, et al.
Publicado: (2022)

DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats
por: Sharma, Puneet K., et al.
Publicado: (2020)

SV40 and human mesothelioma
por: Carbone, Michele, et al.
Publicado: (2020)

Designing disorder: Tales of the unexpected tails
por: Minde, David P, et al.
Publicado: (2013)

Difference between affected and unaffected sides of forearm bone length in children with congenital terminal transverse deficiencies at the level of carpal bone
por: Nishizaka, Chika, et al.
Publicado: (2024)

Evaluating the In Vivo Specificity of [(18)F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET
por: Serrano, Maria Elisa, et al.
Publicado: (2019)

Detection is unaffected by the deployment of focal attention
por: Moher, Jeff, et al.
Publicado: (2013)

Blur Detection is Unaffected by Cognitive Load
por: Loschky, Lester C., et al.
Publicado: (2014)

SV40: A Human Pathogen?
por: Garcea, Robert L.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_arblo9mhi1mtuidqgdgekf5m53