GD2-targeted chimeric antigen receptor T cells prevent metastasis formation by elimination of breast cancer stem-like cells

Expression of the disialoganglioside GD2 has been identified as a marker antigen associated with a breast cancer stem-like cell (BCSC) phenotype. Here, we report on the evaluation of GD2 as a BCSC-specific target antigen for immunotherapy. GD2 expression was confirmed at variable degree in a set of...

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Detalles Bibliográficos
Autores principales: Seitz, Christian M., Schroeder, Sarah, Knopf, Philipp, Krahl, Ann-Christin, Hau, Jana, Schleicher, Sabine, Martella, Manuela, Quintanilla-Martinez, Leticia, Kneilling, Manfred, Pichler, Bernd, Lang, Peter, Atar, Daniel, Schilbach, Karin, Handgretinger, Rupert, Schlegel, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959445/
https://www.ncbi.nlm.nih.gov/pubmed/32002293
http://dx.doi.org/10.1080/2162402X.2019.1683345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959445/
https://www.ncbi.nlm.nih.gov/pubmed/32002293
http://dx.doi.org/10.1080/2162402X.2019.1683345

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