Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies

Glucocorticoids mediate potent anti-inflammatory and immunosuppressive effects. A chronic elevation of the endogenous glucocorticoid tonus subsequent to mental stress, as well as continuous treatment with exogenous glucocorticoids, activate an immunosuppressive transcription factor, TSC22D3, in dend...

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Detalles Bibliográficos
Autores principales: Ma, Yuting, Yang, Heng, Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959448/
https://www.ncbi.nlm.nih.gov/pubmed/32002285
http://dx.doi.org/10.1080/2162402X.2019.1673635
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author Ma, Yuting
Yang, Heng
Kroemer, Guido
author_facet Ma, Yuting
Yang, Heng
Kroemer, Guido
author_sort Ma, Yuting
collection PubMed
description Glucocorticoids mediate potent anti-inflammatory and immunosuppressive effects. A chronic elevation of the endogenous glucocorticoid tonus subsequent to mental stress, as well as continuous treatment with exogenous glucocorticoids, activate an immunosuppressive transcription factor, TSC22D3, in dendritic cells, causing the subversion of cancer therapy-elicited antineoplastic immune responses and subsequent therapeutic failure.
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spelling pubmed-69594482020-01-30 Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies Ma, Yuting Yang, Heng Kroemer, Guido Oncoimmunology Author's View Glucocorticoids mediate potent anti-inflammatory and immunosuppressive effects. A chronic elevation of the endogenous glucocorticoid tonus subsequent to mental stress, as well as continuous treatment with exogenous glucocorticoids, activate an immunosuppressive transcription factor, TSC22D3, in dendritic cells, causing the subversion of cancer therapy-elicited antineoplastic immune responses and subsequent therapeutic failure. Taylor & Francis 2019-10-11 /pmc/articles/PMC6959448/ /pubmed/32002285 http://dx.doi.org/10.1080/2162402X.2019.1673635 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's View
Ma, Yuting
Yang, Heng
Kroemer, Guido
Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies
title Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies
title_full Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies
title_fullStr Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies
title_full_unstemmed Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies
title_short Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies
title_sort endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959448/
https://www.ncbi.nlm.nih.gov/pubmed/32002285
http://dx.doi.org/10.1080/2162402X.2019.1673635
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