Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72

[Image: see text] The covalent inhibition mechanism of action, which overcomes competition with high-affinity, high-abundance substrates of challenging protein targets, can deliver effective chemical probes and drugs. The success of this strategy has centered on exposed cysteine residues as nucleoph...

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Detalles Bibliográficos
Autores principales: Pettinger, Jonathan, Carter, Michael, Jones, Keith, Cheeseman, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959841/
https://www.ncbi.nlm.nih.gov/pubmed/31725295
http://dx.doi.org/10.1021/acs.jmedchem.9b01709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959841/
https://www.ncbi.nlm.nih.gov/pubmed/31725295
http://dx.doi.org/10.1021/acs.jmedchem.9b01709

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