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Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72
[Image: see text] The covalent inhibition mechanism of action, which overcomes competition with high-affinity, high-abundance substrates of challenging protein targets, can deliver effective chemical probes and drugs. The success of this strategy has centered on exposed cysteine residues as nucleoph...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959841/ https://www.ncbi.nlm.nih.gov/pubmed/31725295 http://dx.doi.org/10.1021/acs.jmedchem.9b01709 |