MutSα’s Multi-Domain Allosteric Response to Three DNA Damage Types Revealed by Machine Learning

MutSα is a key component in the mismatch repair (MMR) pathway. This protein is responsible for initiating the signaling pathways for DNA repair or cell death. Herein we investigate this heterodimer’s post-recognition, post-binding response to three types of DNA damage involving cytotoxic, anti-cance...

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Detalles Bibliográficos
Autores principales: Melvin, Ryan L., Thompson, William G., Godwin, Ryan C., Gmeiner, William H., Salsbury, Freddie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959842/
https://www.ncbi.nlm.nih.gov/pubmed/31938712
http://dx.doi.org/10.3389/fphy.2017.00010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959842/
https://www.ncbi.nlm.nih.gov/pubmed/31938712
http://dx.doi.org/10.3389/fphy.2017.00010

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