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MutSα’s Multi-Domain Allosteric Response to Three DNA Damage Types Revealed by Machine Learning
MutSα is a key component in the mismatch repair (MMR) pathway. This protein is responsible for initiating the signaling pathways for DNA repair or cell death. Herein we investigate this heterodimer’s post-recognition, post-binding response to three types of DNA damage involving cytotoxic, anti-cance...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959842/ https://www.ncbi.nlm.nih.gov/pubmed/31938712 http://dx.doi.org/10.3389/fphy.2017.00010 |