Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

Induction of intestinal drug metabolizing enzymes can complicate the development of new drugs, owing to the potential to cause drug-drug interactions (DDIs) leading to changes in pharmacokinetics, safety and efficacy. The development of a human-relevant model of the adult intestine that accurately p...

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Detalles Bibliográficos
Autores principales: Kasendra, Magdalena, Luc, Raymond, Yin, Jianyi, Manatakis, Dimitris V, Kulkarni, Gauri, Lucchesi, Carolina, Sliz, Josiah, Apostolou, Athanasia, Sunuwar, Laxmi, Obrigewitch, Jenifer, Jang, Kyung-Jin, Hamilton, Geraldine A, Donowitz, Mark, Karalis, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959988/
https://www.ncbi.nlm.nih.gov/pubmed/31933478
http://dx.doi.org/10.7554/eLife.50135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959988/
https://www.ncbi.nlm.nih.gov/pubmed/31933478
http://dx.doi.org/10.7554/eLife.50135

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