Acute cerebellar knockdown of Sgce reproduces salient features of myoclonus-dystonia (DYT11) in mice

Myoclonus dystonia (DYT11) is a movement disorder caused by loss-of-function mutations in SGCE and characterized by involuntary jerking and dystonia that frequently improve after drinking alcohol. Existing transgenic mouse models of DYT11 exhibit only mild motor symptoms, possibly due to rodent-spec...

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Detalles Bibliográficos
Autores principales: Washburn, Samantha, Fremont, Rachel, Moreno-Escobar, Maria Camila, Angueyra, Chantal, Khodakhah, Kamran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959989/
https://www.ncbi.nlm.nih.gov/pubmed/31868164
http://dx.doi.org/10.7554/eLife.52101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959989/
https://www.ncbi.nlm.nih.gov/pubmed/31868164
http://dx.doi.org/10.7554/eLife.52101

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